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2024年12月28日发(作者：java手机编辑器中文版)

专利内容由知识产权出版社提供

专利名称：APPLICATIONS OF LASER-PROCESSED

SUBSTRATE FOR MOLECULAR DIAGNOSTICS

发明人：EBSTEIN, STEVEN M.

申请号：EP06784916

申请日：20060614

公开号：EP1896805A4

公开日：20100331

摘要：Surface enhanced Raman Scattering (SERS) and related modalities offer greatly

enhanced sensitivity and selectivity for detection of molecular species through the

excitation of plasmon modes and their coupling to molecular vibrational modes. One of

the chief obstacles to widespread application is the availability of suitable nanostructured

materials that exhibit strong enhancement of Raman scattering, are inexpensive to

fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other

photonic sensing that use semiconductor and metal surfaces fabricated using

femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto

the resulting nanostructured surfaces for use as a substrate for SERS . These surfaces are

inexpensive to produce and can have their statistical properties precisely tailored by

varying the laser processing. Surfaces can be readily micropatterned and both stochastic

and self-organized structures can be fabricated. This material has application to a variety

of genomic, proteomic, and biosensing applications including label free applications

including binding detection. Using this material, monolithic or arrayed substrates can be

designed. Substrates for cell culture and microlabs incorporating microf luidics and

electrochemical processing can be fabricated as well. Laser processing can be used to

form channels in the substrate or a material sandwiched onto it in order to introduce

reagents and drive chemical reactions. The substrate can be fabricated so application of

an electric potential enables separation of materials by electrophoresis or electro-

osmosis.

申请人：EBSTEIN, STEVEN M.

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