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2024年3月11日发(作者：wxpython builder)

专利内容由知识产权出版社提供

专利名称：Organogenesis from dissociated cells

发明人：Ying Zheng,Xiaobing Du,Wei Wang,Marylene

Boucher,Satish Parimoo,Kurt Stricker Stenn

申请号：US11203804

申请日：20050815

公开号：US2A1

公开日：20060323

专利附图：

摘要：A method assay for rapidly and reproducibly generating hair follicles from

dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a

tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for

studying the mechanisms dissociated cells employ to assemble an organ. In a method of

this application dissociated cells, isolated from newborn mouse skin, are injected into

adult mouse truncal skin, hair follicles develop. This process involves the aggregation of

epithelial cells to form clusters which are sculpted by apoptosis to generate

“infundibular cysts”. From the “infundibular cysts” hair germs form followed by

follicular buds and then pegs which grow asymmetrically to differentiate into cycling

mature pilosebaceous structures. Using various techniques, exposure of the

“infundibular cysts” by puncturing, piercing, or scratching the skin and, in an approach,

covering the exposed cysts with a wound dressing material produced egressing hair

follicles.

申请人：Ying Zheng,Xiaobing Du,Wei Wang,Marylene Boucher,Satish Parimoo,Kurt

Stricker Stenn

地址：West Chester PA US,Philadelphia PA US,Paoli PA US,Philadelphia PA

US,Bridgewater NJ US,Princeton NJ US

国籍：US,US,US,US,US,US

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