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2024年12月28日发(作者：plc基础知识大全解析)

专利内容由知识产权出版社提供

专利名称：ENZYMES

申请号：AU5203773

申请日：19730209

公开号：AU469805B2

公开日：19760226

摘要：1415597 Reactions with absorbed enzymes NATIONAL PATENT DEVELOPMENT

CORP 1 Feb 1973 [11 Feb 1972] 5197/73 Heading B1X [Also in Divisions C3 and G1] A

process for subjecting a blood or body fluid containing an

enzymesusceptible material to the action of an enzyme comprises permitting the

enzyme-susceptible material of the substrate to come into contact with the enzyme

entrapped or encapsulated within a water-insoluble hydrophilic polymer of a monomer

of the group consisting of hydroxy lower alkyl (i.e. C 1 -C 3 ) acrylates, hydroxy lower

alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy

lower alkyl methacrylates with or without a proportion of vinyl pyrrolidone, acrylamide,

methacrylamide, N- lower alkyl acrylamide, N-lower alkyl methacrylamide, N-hydroxy

lower alkyl acrylamide, and N-hydroxy lower alkyl methacrylamide. The water insoluble

hydrophilic polymer may be in the form of a hollow tube having a relatively thin overall

internal semipermeable membrane coating of a polymer as above, but enzyme free, the

semi-permeable membrane being permeable to the enzyme-susceptible material but

not to the enzyme. In Fig. 3 a tube 18, shown in crosssection, comprises a lumen 20, a

urease containing polymer layer 22 containing a reinforcing sheathing of polyethylene

terephthalate and, optionally, inner and outer coatings of water insoluble hydroxyethyl

methacrylate polymer. When a solution of urea is forced through the lumen of the tube

the solution diffuses to the enzyme entrapped tube and ammonia diffuses out of the

outer surface of the tube thus enabling the purification of body blood to

eliminate urea.

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